Advances in the Diagnosis and Management of Cardiac Arrhythmias: A Global Perspective with Regional Insights from Latin America
DOI:
https://doi.org/10.64784/015Palabras clave:
Atrial fibrillation, Arrhythmia management, Artificial intelligence, Catheter ablation, Electrophysiology, Latin America, Telecardiology, Ventricular arrhythmiaResumen
Cardiac arrhythmias remain one of the leading causes of cardiovascular morbidity and mortality worldwide. Over the past decade, diagnostic and therapeutic approaches have undergone a profound transformation driven by technological innovation, artificial intelligence (AI), and evidence-based medicine. This review analyzes the main advances in arrhythmia diagnosis and management, emphasizing the global perspective and its implementation in Latin America, particularly in Mexico, Colombia, and Ecuador. A narrative review was conducted using the Scientific Method and the DMAIC framework, analyzing twenty peer-reviewed publications, clinical trials, and international guidelines published between 2014 and 2024. The evidence reveals a transition from conventional electrocardiographic methods such as 24-hour Holter monitoring to extended adhesive patch ECGs, implantable loop recorders, and wearable devices supported by AI algorithms, which have significantly improved diagnostic precision and early detection of subclinical arrhythmias. Therapeutically, clinical trials such as EAST-AFNET 4, CABANA, EARLY-AF, and STOP AF First demonstrated that early rhythm-control strategies, particularly catheter and cryoballoon ablation, provide better rhythm maintenance, reduce cardiovascular events, and modify the natural course of atrial fibrillation. Furthermore, the integration of telecardiology, device remote monitoring, and cardiogenetic evaluation is progressively redefining contemporary arrhythmia care. Despite persistent disparities in access and infrastructure, Latin American countries are adopting hybrid diagnostic and therapeutic models aligned with international standards. In conclusion, modern arrhythmia management has evolved into a proactive, technology-driven, and patient-centered discipline, where early rhythm control, AI-assisted monitoring, and regional collaboration are essential to improve outcomes and achieve equitable cardiovascular care worldwide.
Referencias
Andrade, J. G., Deyell, M. W., Macle, L., Wells, G. A., Bennett, M., Essebag, V., … Verma, A. (2021). Cryoablation or antiarrhythmic drugs as initial therapy for atrial fibrillation (EARLY-AF). New England Journal of Medicine, 384(4), 305–315. https://doi.org/10.1056/NEJMoa2029980
Barrett, P. M., Komatireddy, R., Haaser, S., Topol, S., Sheard, J., Encinas, J., … Topol, E. J. (2014). Comparison of 24-hour Holter monitoring versus 14-day continuous adhesive patch electrocardiographic monitoring. The American Journal of Medicine, 127(1), 95.e11–95.e17. https://doi.org/10.1016/j.amjmed.2013.10.003
Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., … ESC Scientific Document Group. (2021). 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy. European Heart Journal, 42(35), 3427–3520. https://doi.org/10.1093/eurheartj/ehab364
Hannun, A. Y., Rajpurkar, P., Haghpanahi, M., Tison, G. H., Bourn, C., Turakhia, M. P., & Ng, A. Y. (2019). Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network. Nature Medicine, 25(1), 65–69. https://doi.org/10.1038/s41591-018-0268-3
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström-Lundqvist, C., … ESC Scientific Document Group. (2021). 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS). European Heart Journal, 42(5), 373–498. https://doi.org/10.1093/eurheartj/ehaa612
Jiang, H., Liu, M., Li, C., Liu, Y., Chen, J., Zhao, L., & Zhang, Y. (2022). Extended electrocardiographic monitoring to detect atrial fibrillation: A systematic review and meta-analysis. Open Heart, 9(2), e002081. https://doi.org/10.1136/openhrt-2022-002081
Joglar, J. A., Chung, M. K., Gheorghiade, M., Go, A. S., Hsu, J. C., Knight, B. P., … American Heart Association Task Force. (2024). 2023 ACC/AHA/ACCP/HRS guideline for the diagnosis and management of atrial fibrillation. Circulation, 149(5), e***–e***. https://doi.org/10.1161/CIR.0000000000001193
Kim, J. A., & Chelu, M. G. (2021). Inherited arrhythmia syndromes. Texas Heart Institute Journal, 48(4), e207482. https://doi.org/10.14503/THIJ-20-7482
Kirchhof, P., Camm, A. J., Goette, A., Brandes, A., Eckardt, L., Elvan, A., … Early Rhythm-Control Therapy in Atrial Fibrillation Investigators. (2020). Early rhythm-control therapy in patients with atrial fibrillation. New England Journal of Medicine, 383(14), 1305–1316. https://doi.org/10.1056/NEJMoa2019422
Könemann, S., Nasir, J. M., Bhatt, D. L., … Zeppenfeld, K. (2023). Global perspectives on ventricular arrhythmia management: State-of-the-art review. JACC: Clinical Electrophysiology, 9(10), 1960–1974. https://doi.org/10.1016/j.jacep.2023.05.016
Kotadia, I. D., Williams, S. E., & O’Neill, M. (2020). Supraventricular tachycardia: Overview of diagnosis and management. Clinical Medicine (London), 20(1), 43–47. https://doi.org/10.7861/clinmed.cme.20.1.3
Packer, D. L., Mark, D. B., Robb, R. A., Monahan, K. H., Bahnson, T. D., Poole, J. E., … CABANA Investigators. (2019). Catheter ablation versus antiarrhythmic drug therapy for atrial fibrillation: The CABANA randomized clinical trial. JAMA, 321(13), 1261–1274. https://doi.org/10.1001/jama.2019.0693
Perez, M. V., Mahaffey, K. W., Hedlin, H., Rumsfeld, J. S., Garcia, A., Ferris, T., … Turakhia, M. P. (2019). Large-scale assessment of a smartwatch to identify atrial fibrillation. New England Journal of Medicine, 381(20), 1909–1917. https://doi.org/10.1056/NEJMoa1901183
Sanna, T., Diener, H. C., Passman, R. S., Di Lazzaro, V., Bernstein, R. A., Morillo, C. A., … CRYSTAL AF Investigators. (2014). Cryptogenic stroke and underlying atrial fibrillation. New England Journal of Medicine, 370(26), 2478–2486. https://doi.org/10.1056/NEJMoa1313600
Sarquella-Brugada, G., Cesar, S., Campuzano, O., & Brugada, R. (2024). Inherited arrhythmogenic syndromes in the young: Genetic diagnosis and exercise recommendations. BMJ Open Sport & Exercise Medicine, 10(3), e001852. https://doi.org/10.1136/bmjsem-2023-001852
Specterman, M. J., & Behr, E. R. (2022). Cardiogenetics: The role of genetic testing for inherited arrhythmia syndromes and sudden death. Heart, 108(2), 1–8. https://doi.org/10.1136/heartjnl-2021-320015
Wazni, O. M., Dandamudi, G., Sood, N., Hoyt, R., Tyler, J., Durrani, S., … STOP AF First Investigators. (2021). Cryoballoon ablation as initial therapy for atrial fibrillation. New England Journal of Medicine, 384(4), 316–324. https://doi.org/10.1056/NEJMoa2029554
Zeppenfeld, K., Tfelt-Hansen, J., de Riva, M., Winkel, B. G., Behr, E. R., Blom, N. A., … ESC Scientific Document Group. (2022). 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. European Heart Journal, 43(40), 3997–4126. https://doi.org/10.1093/eurheartj/ehac262